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MYP_165169
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Basic Information
HPA3NT3-A2 (HPA3NT3 peptide analogs)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
15 amino acids
C94H161N27O16
Standard
Sequence
AKRLKKLAKKIWKWK
Physicochemical Analysis
1925.46 Da
11.47
7.79
7.59
0.5193
-1.19
0.83
-0.44
14.09
91.33
0.1333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
746.34
-1.02
28.0
24.0
71.0
137.0
4.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0249698 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HPA3
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
D-Lys at 2nd, 5th, 6th, 9th, 10th, 13th, and 15th position
Bio-Activity Profile
Antimicrobial Antibacterial
Salmonella typhimurium CCARM 8013
4 μM
MIC
Remaining 100% more than 120 min
PaperLee JK, Park Y All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance Int J Mol Sci. 2020 Aug 6;21(16):5632. PMID:32781586 https://pubmed.ncbi.nlm.nih.gov/32781586/ PMID32781586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32781586/
RECORD: Rec_0250999 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 60.0%, E 0.0%, T 20.0%, C 20.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0273691 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis
2 μM
MIC
PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 32781586 PMID22982494;32781586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0283321 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HPA3
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
D-Lys at 2nd, 5th, 6th, 9th, 10th, 13th, and 15th position
Bio-Activity Profile
Antimicrobial Antibacterial
Salmonella typhimurium CCARM 8009
8 μM
MIC
Remaining 100% more than 120 min
PaperLee JK, Park Y All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance Int J Mol Sci. 2020 Aug 6;21(16):5632. PMID:32781586 https://pubmed.ncbi.nlm.nih.gov/32781586/ PMID32781586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32781586/
RECORD: Rec_0284282 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial
Escherichia coli
4 μM
MIC
Unspecified 60 min
PaperAntimicrobial peptide HPA3NT3-A2 effectively inhibits biofilm formation in mice infected with drug-resistant bacteria.
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