Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length585 amino acids

Chemical FormulaC3023H4767N749O871S20

DescriptionStandard

        MKLLEQELRTRIFPDETGTEKYFFGIIDYTVSSDYQGEVKISILELSITTNMIVAQNNRGDLLVSVQNCQLSTGNIEVQLNSEGRWYYNAFVQHLEKVIRTRLESQLCLNVILRIQKETEVLKGLKGVFQINPFIQVKYSLITPPEVFKSYVDLDFKVSVYFSSNHTESPFVAAPFTLPEKNNYMLFGGISESLLNSITLTYYTTRVSKHSSYFNLTTDTLSGIIPQVMQHYTKSHPVRMKLMVTAAPVLRLQNNSFTIEIPCFVVVSALLSNSMIKPIFAVNASIGLKANAVIAKQKLIVLLQLQRLYLSLTYSSIGSFQVQRLKNFLSYSLQNTVIPPITGNQFGVELLKQKLKEKTSEDWNGESTYGFFALNYTISKIRIDNVEFPNTSLSLISGTGIKLLVENASAIATADWSVETWLLWLYTYSTASLVTSLCSMLATNLCQQVNFVIQKINKDFSQYPGISEYFLQSASLAYYTSGAFTISAEQEEMISHIYAKPLPVIMNLRIIDAPVISLHDNKSILEFSASMEVLAKMPNSTTESMFTLNIVVIKLKDGFPLPVLDPIILMKPNIRIYEQLMYIYR
    

Molecular Weight66180.98 Da

Isoelectric Point (pI)8.04

Net Charge (pH 7.0)2.11

Net Charge (pH 7.4) 1.31

Charge Density (pH 7.0) 0.0036

GRAVY Index0.12

Hydrophobic Moment 0.78

Boman Index0.14

Instability Index32.90

Aliphatic Index 106.60

Aromaticity 0.1060

Extinction Coeff. Reduced 69220.00

Extinction Coeff. Oxidized 69470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0071162 VERIFIED: NO

Provenance & Taxonomy

OrganismOphiophagus hannah [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence