Peptide Database

Peptide NameSLAY-screened peptide P2566

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC91H133N25O26S

DescriptionStandard

        HPDHGLSALFHTGMYAASL
    

Molecular Weight2025.25 Da

Isoelectric Point (pI)6.25

Net Charge (pH 7.0)-0.98

Net Charge (pH 7.4) -1.33

Charge Density (pH 7.0) -0.0515

GRAVY Index0.13

Hydrophobic Moment 0.31

Boman Index0.30

Instability Index15.02

Aliphatic Index 77.37

Aromaticity 0.1053

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 782.59

LogP -7.23

H-bond Donors 27.0

H-bond Acceptors 29.0

Rotatable Bonds 60.0

Heavy Atoms 143.0

Ring Count 6.0

Amide Bonds 18.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0333873 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/