Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2391H3798N608O674S18

DescriptionStandard

        DKGKKMLKTWYYFLLCWLASQLEANPGLKVRITQKGLDYGRRIGVELLKQAVLKETFPSWSGQESFLVAKVNYVISRLRINAVDFPETSASFIPGTGISLSVARASATVSADWRLNTWLLEDQGGITLSISGLFIEVIFKVSRDSTGHLSMLLHNCQMSIDSLKVKLNGGSSWIYSFLLGYLEKPIQTKLDKNLCLNIKYKIQAMDAQLRKHKVLSQIDAFAQIDYSLVSSPAVFKSHINFDLKGTVCPVGNCTEPPFVPAPFALPNQSDSMLYLGVSSYFLKSASLAYYRAGVFNITISEELATTFNLNTTLFKDFVPEIALSCVTVCPMLLKLMATSPPVVSLNTDRCLLQITGCVDVFAVLPNSTTQYIFTGNLTASTRANMTITKQKLSISLLLKRLQFSLLHSTLGFSENMSLVENFLSFALRTAVIPEINDKLEKGFPLNLVHTILAGPVIKINQGHLVISTDVHYK
    

Molecular Weight52422.57 Da

Isoelectric Point (pI)9.10

Net Charge (pH 7.0)11.39

Net Charge (pH 7.4) 10.54

Charge Density (pH 7.0) 0.0241

GRAVY Index0.21

Hydrophobic Moment 0.72

Boman Index0.15

Instability Index34.69

Aliphatic Index 106.96

Aromaticity 0.0951

Extinction Coeff. Reduced 53860.00

Extinction Coeff. Oxidized 54360.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0203173 VERIFIED: NO

Provenance & Taxonomy

OrganismMerops nubicus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria