MYP_165058
[R15A, R17A]GeXIVA[1,2]
Anticancer
Antimicrobial
Standard
28 amino acids
C133H217N49O41S4
Standard
TCRSSGRYCRSPYDARARYCRRITDACV
3286.71 Da
9.57
4.36
4.10
0.1556
-0.86
0.77
-0.47
100.13
35.00
0.1071
4470.00
4720.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1509.97
-20.52
63.0
50.0
104.0
227.0
4.0
27.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0292246
VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Conotoxin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
α9α10 nicotinic acetylcholine receptor antagonist
Receptor inhibitory
RECORD: Rec_0433533
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Conotoxin
Structure & Mods
linear peptide with two intramolecular disulfide bonds [Linear]
canonical L-amino-acid peptide [L]
Two disulfide bonds; [1,2] bead connectivity
Alanine substitutions R15A and R17A
Bio-Activity Profile
α9α10 nicotinic acetylcholine receptor antagonist
Receptor inhibitory
rat α9α10 nicotinic acetylcholine receptor expressed in Xenopus oocytes
230 (95% CI 165–307) nM
IC50; two-electrode voltage-clamp electrophysiology