Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length493 amino acids

Chemical FormulaC2473H3861N621O727S19

DescriptionStandard

        MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEQKLPDLSGSESLEFLKVDYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKVTLSSSESSACNSMLYIGIAEYFFKSASFAHFTAGAFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPMINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFINSDIEVLEGFLLISTDLKYETSSKQQPSFHGWEGLNLISGQWRGKSAP
    

Molecular Weight54533.07 Da

Isoelectric Point (pI)5.45

Net Charge (pH 7.0)-9.72

Net Charge (pH 7.4) -10.59

Charge Density (pH 7.0) -0.0197

GRAVY Index0.14

Hydrophobic Moment 0.68

Boman Index0.17

Instability Index38.62

Aliphatic Index 100.87

Aromaticity 0.0994

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50225.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0039267 VERIFIED: NO

Provenance & Taxonomy

OrganismPan paniscus [Animal]

FamilyBPI

Tax ID9597

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence