MYP_165002
xStAx, aStAx-35R
Anticancer
Antimicrobial
Antimicrobial
▸
Antibacterial
Standard
17 amino acids
C105H170N42O22
Standard
RRWPRRILDDHVRRVWR
2372.74 Da
12.00
4.85
4.59
0.2853
-1.67
0.85
-0.80
151.08
80.00
0.1176
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1088.29
-7.73
43.0
28.0
76.0
169.0
6.0
16.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0163911
VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Axin-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
β-catenin/TCF4 interaction inhibitor
Wnt signaling inhibitor
Anticancer
RECORD: Rec_0433532
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Axin-derived stapled peptide
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Hydrocarbon stapling; N-terminal acetylation; C-terminal amidation
Bio-Activity Profile
β-catenin/TCF4 interaction inhibitor
Wnt signaling inhibitor
Anticancer
β-catenin/TCF4 complex; Wnt-dependent colorectal cancer cells (DLD1, SW480, HCT116)
β-catenin/TCF4 pull-down, TOPFlash reporter and cell-proliferation assays