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MYP_164927
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Basic Information
Holothuroidin 1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
12 amino acids
C63H99N21O15
Standard
Sequence
HLGHHALDHLLK
Physicochemical Analysis
1390.59 Da
7.10
0.11
-0.30
0.0091
-0.30
0.50
0.11
2.09
138.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
561.46
-2.97
19.0
19.0
45.0
99.0
4.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0326827 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa ATCC 15442
2.231 μM
Safranin staining
RECORD: Rec_0332346 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa
125 μg/mL
MIC
RECORD: Rec_0391825 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus aureus ATCC 25923
2.303, 1.079 μM
Safranin staining
RECORD: Rec_0406983 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0414858 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 15442
12500 μg/mL
MIC
PMID23800329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23800329/
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