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MYP_164927
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Basic Information
Holothuroidin 1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
12 amino acids
C63H99N21O15
Standard
Sequence
HLGHHALDHLLK
Physicochemical Analysis
1390.59 Da
7.10
0.11
-0.30
0.0091
-0.30
0.50
0.11
2.09
138.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
561.46
-2.97
19.0
19.0
45.0
99.0
4.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0167980 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus epidermidis ATCC 35984
1.079 μM
Safranin staining
RECORD: Rec_0175576 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis ATCC 29212
12500 μg/mL
MIC
PMID23800329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23800329/
RECORD: Rec_0263381 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 35984, and Pseudomonas aeruginosa ATCC 15442
12500 μg/mL
MIC
PaperImmune mediators of sea-cucumber Holothuria tubulosa (Echinodermata) as source of novel antimicrobial and anti-staphylococcal biofilm agents
RECORD: Rec_0294056 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 16.7%, T 33.3%, C 50.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperBaAMPs: the database of biofilm-active antimicrobial peptides PMID25760404 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25760404/
RECORD: Rec_0314604 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis ATCC 35984
12500 μg/mL
MIC
PMID23800329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23800329/
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