Peptide Database

Peptide NameSLAY-screened peptide P2227

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H148N24O27S2

DescriptionStandard

        CLPNGVPTPNCYIVHFTALS
    

Molecular Weight2146.49 Da

Isoelectric Point (pI)6.72

Net Charge (pH 7.0)-0.17

Net Charge (pH 7.4) -0.46

Charge Density (pH 7.0) -0.0087

GRAVY Index0.56

Hydrophobic Moment 0.25

Boman Index0.35

Instability Index20.00

Aliphatic Index 92.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 785.63

LogP -7.25

H-bond Donors 27.0

H-bond Acceptors 30.0

Rotatable Bonds 59.0

Heavy Atoms 150.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0204668 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/