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MYP_164917
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Basic Information
Leptoglycin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
22 amino acids
C79H136N22O23
Standard
Sequence
GLLGGLLGPLLGGGGGGGGGLL
Physicochemical Analysis
1762.06 Da
5.53
-0.24
-0.44
-0.0109
1.07
0.21
0.67
60.03
141.82
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
665.63
-7.34
22.0
23.0
58.0
124.0
1.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027046 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pentadactylus [Animal]; Rana pentadactyla [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa
8 μM
MIC
RECORD: Rec_0040217 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pentadactylus [Animal]
Leptoglycin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
50.0 μM
MIC
PaperJ.C. Sousa et al. / Toxicon 54 (2009) 23-32. Leptoglycin: A new Glycine/Leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae) Evidence URLhttps://www.uniprot.org/uniprotkb/P86267/entry
RECORD: Rec_0070176 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pentadactylus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Pseudomonas aeruginosa
8 μM
MIC
PaperLeptoglycin: a new Glycine/Leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae).
RECORD: Rec_0117740 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 9.1%, T 68.2%, C 22.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-negative
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0129966 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pentadactylus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PMID19298834 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19298834/
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