Peptide Database

Peptide NameSLAY-screened peptide P4278

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC125H173N29O34

DescriptionStandard

        PTYTRQYDRTHEPVYYFYLL
    

Molecular Weight2625.88 Da

Isoelectric Point (pI)7.15

Net Charge (pH 7.0)0.04

Net Charge (pH 7.4) -0.07

Charge Density (pH 7.0) 0.0022

GRAVY Index-0.99

Hydrophobic Moment 0.60

Boman Index-0.11

Instability Index57.15

Aliphatic Index 53.50

Aromaticity 0.3000

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1025.45

LogP -5.49

H-bond Donors 38.0

H-bond Acceptors 35.0

Rotatable Bonds 76.0

Heavy Atoms 188.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0024303 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/