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MYP_164845
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Basic Information
ACE2 (4-13)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
10 amino acids
C53H85N13O19
Standard
Sequence
EEQAKTFLDK
Physicochemical Analysis
1208.32 Da
4.68
-1.16
-1.34
-0.1161
-1.41
0.44
-0.34
64.71
49.00
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
552.48
-4.82
18.0
18.0
43.0
85.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006730 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Vesicular Stomatitis Virus (VSV) PsV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0008719 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-CoV | HeLa cells
100 μM
% inhibition
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperIdentification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor. | Han DP, Penn-Nicholson A, Cho MW. | Virology. 2006 Jun 20;350(1):15-25. | DOI:10.1016/j.virol.2006.01.029 | PMID:16510163 PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0020457 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV PsV
20-30 % Inhibition
Inhibition
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0375853 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0383957 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/