Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length447 amino acids

Chemical FormulaC2190H3559N583O620S17

DescriptionStandard

        MSLCCWFILVALISTTSSKNPGVKVKLTQKGIEYGRQLGMASIQQKLKTIKIPDMSGKQRVSPIGKVKYSLSNIQIVNVGLPESGVTLVPGTGVRLSIGNANLSLRGRWRVKYFRIIKDRGSFDLSVTGLSISPSIAVKSDERGRPAVSAVNCAATVSSVRVKFHGGASWLYNLFKKFINRALQKTVQKQMCPLVANAISDLNPQLKTLNVLAKVDKHAEIEYSMVASPTVTKSSLDLSLKGEFYKIGGHQEPPFSPVAFSLPPQINNMLYMGMSSFTVNSAGFVYNRAGVLTLSITDDMIPKISPVRLSTRTFGTFIPEISRRFPGLLVKLQVKTVKDPVVTFEPNNATIQATGSVTAFAIQPNSTLTPLFVLNLDTSVSTKLFVSGMRLAGAVSLNKMALTLGTSYVGKFEGYPLPAIGKMKLVNTQVQVLKDYMLIGTDVQFAS
    

Molecular Weight48521.32 Da

Isoelectric Point (pI)10.06

Net Charge (pH 7.0)28.72

Net Charge (pH 7.4) 28.20

Charge Density (pH 7.0) 0.0643

GRAVY Index0.13

Hydrophobic Moment 0.75

Boman Index0.11

Instability Index35.90

Aliphatic Index 99.15

Aromaticity 0.0761

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0215689 VERIFIED: NO

Provenance & Taxonomy

OrganismSeriola dumerili [Bacterium]

FamilyBPI

Tax ID41447

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence