‹ ›
MYP_164779
← PREVIOUS NEXT → BACK
Basic Information
DGL13K (De Novo Synthesis)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C68H129N17O15
Standard
Sequence
GKIIKLKASLKLL
Physicochemical Analysis
1424.86 Da
10.48
3.76
3.55
0.2889
0.71
0.25
0.15
-36.48
187.69
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
536.83
-1.35
19.0
19.0
54.0
100.0
0.0
12.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0190791 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA300
5.2 μg/mL
MIC
PMID31071184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31071184/
RECORD: Rec_0196191 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
10.4 μg/mL
MIC
PMID31071184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31071184/
RECORD: Rec_0218253 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PMID31071184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31071184/
RECORD: Rec_0220766 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa PAO1 / ATCC 15692
44.944, 22.472 μM
Total countable CFUs
RECORD: Rec_0258561 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Parotid secretory protein [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Interestingly, CD spectra suggest a beta structure in liposomes containing aninoic lipid PGs (Balhara V et al., 2013). Note that the peptide is random coil in water, but adopted a helical structure in DPC, indicating structural plasticity. Design: GL13K is obtained by substituting 3 residues (Q2, N5, and D11) of GL13NH2 with lysines. The PSP (Parotid secretory protein) peptide GL13NH2 (sequence GQIINLKASLDLL), which corresponds to a lipopolysaccharide-inhibiting peptide from LBP, binds lipopolysaccharides (BBL) and agglutinated bacteria. GL13NH2 is a potential dual-function host defense salivary protein with agglutination and anti-inflammatory activity (Gorr SU et al. 2011), but it did not kill bacteria
Bio-Activity Profile
Antimicrobial Anti-inflammatory
Staphylococcus aureus
41 μg/mL
MIC
PaperHuman parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain.
FIRST PREV 1 2 3 4 5 6 NEXT LAST
Showing 5 records on this page · Page 3 of 6