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MYP_164779
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Basic Information
DGL13K (De Novo Synthesis)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C68H129N17O15
Standard
Sequence
GKIIKLKASLKLL
Physicochemical Analysis
1424.86 Da
10.48
3.76
3.55
0.2889
0.71
0.25
0.15
-36.48
187.69
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
536.83
-1.35
19.0
19.0
54.0
100.0
0.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0061328 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Staphylococcus aureus Xen36
83.3 μg/mL
MIC
PMID31071184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31071184/
RECORD: Rec_0112109 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Parotid secretory protein [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Interestingly, CD spectra suggest a beta structure in liposomes containing aninoic lipid PGs (Balhara V et al., 2013). Note that the peptide is random coil in water, but adopted a helical structure in DPC, indicating structural plasticity. Design: GL13K is obtained by substituting 3 residues (Q2, N5, and D11) of GL13NH2 with lysines. The PSP (Parotid secretory protein) peptide GL13NH2 (sequence GQIINLKASLDLL), which corresponds to a lipopolysaccharide-inhibiting peptide from LBP, binds lipopolysaccharides (BBL) and agglutinated bacteria. GL13NH2 is a potential dual-function host defense salivary protein with agglutination and anti-inflammatory activity (Gorr SU et al. 2011), but it did not kill bacteria
Bio-Activity Profile
Antimicrobial Anti-inflammatory
Escherichia coli
5 μg/mL
MIC
PaperHuman parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain.
RECORD: Rec_0133783 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antibiofilm Antibacterial
Porphyromonas gingivalis ATCC 33277
100 μM
Total countable CFUs
RECORD: Rec_0141886 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human blood cells
560 μg/mL
LD50
PMID31071184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31071184/
RECORD: Rec_0156721 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
The cytotoxicity of D-GL13K on HEK cells is 1
PMID31071184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31071184/
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