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MYP_164770
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Basic Information
Leaf cyclotide 1 (Vhl-1; Plant defensin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
31 amino acids
C140H223N35O45S7
Standard
Sequence
SISCGESCAMISFCFTEVIGCSCKNKVCYLN
Physicochemical Analysis
3340.93 Da
5.85
-0.60
-0.90
-0.0192
0.69
0.40
0.22
56.12
72.26
0.0968
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1290.75
-15.43
51.0
52.0
110.0
227.0
3.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0337712 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Methionine oxidation reported
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antifungal Nematocidal Anthelmintic Anti-HIV
HIV
0.87 μM
EC50
PaperPubMed PMID 15824119 | PubMed PMID 20564010 PMID15824119;20564010 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0348255 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Methionine oxidation reported
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antifungal Nematocidal Anthelmintic Anti-HIV
and Candida albicans
PaperPubMed PMID 15824119 | PubMed PMID 20564010 PMID15824119;20564010 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0351898 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Methionine oxidation reported
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antifungal Nematocidal Anthelmintic Anti-HIV Anti-Gram-positive
Staphylococcus aureus
PaperPubMed PMID 15824119 | PubMed PMID 20564010 PMID15824119;20564010 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
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