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MYP_164770
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Basic Information
Leaf cyclotide 1 (Vhl-1; Plant defensin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
31 amino acids
C140H223N35O45S7
Standard
Sequence
SISCGESCAMISFCFTEVIGCSCKNKVCYLN
Physicochemical Analysis
3340.93 Da
5.85
-0.60
-0.90
-0.0192
0.69
0.40
0.22
56.12
72.26
0.0968
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1290.75
-15.43
51.0
52.0
110.0
227.0
3.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024705 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial Antiviral
HIV inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells
0.87 μM
EC50
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 15824119 PMID18008336;15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0060514 VERIFIED: YES
Provenance & Taxonomy
Viola hederaceae [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antiviral
PaperIsolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.
RECORD: Rec_0080516 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 14-28
Bio-Activity Profile
Antimicrobial cyclotide family Antiviral Host defense
PaperPDB 1ZA8 structural record; NMR; chain A; residues 4-31
RECORD: Rec_0116152 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial Antiviral
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 15824119 PMID18008336;15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0124686 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
180952
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-21, 8-23, 13-28
Disulfide bonds between Cys4 and Cys21; Cys8 and Cys23; Cys13 and Cys28.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.87 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
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