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MYP_164763
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Basic Information
[L9]-P18 (analog of P18)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C119H190N28O19
Standard
Sequence
KWKLFKKILKFLHLAKKF
Physicochemical Analysis
2316.96 Da
10.78
6.84
6.58
0.3800
-0.08
0.83
-0.02
-2.36
113.89
0.2222
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
784.63
2.21
28.0
27.0
83.0
166.0
6.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0132631 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
MDA-MB-361
3 μM
IC50
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0132701 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Jurkat
9 μM
IC50
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0136443 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium KCTC 1096
1.56 μM
MIC
PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0143416 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
human red blood cells
100 μg/mL
Hemolysis
PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0158858 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Normal cells NIH 3T3
70 μM
IC50
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
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