Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length452 amino acids

Chemical FormulaC2217H3594N572O642S17

DescriptionStandard

        VTRLSQPSKCYFVLNAGRAIGIESLQQKLRTIQLKDVSGTEKLAIGKVEYSITGMQIVNLGLPKSALRLVAGTGVMLSVGDAYISLRGNWRVKYSWIIKASGSFELAVSELAISTTIAVKSDVTGRPTVSVTKCEATVGSVKVRFSGGASWLYNLFDSFINKALRNALQKQICPLVTASIAEMNKNLKTLNVLAKVDQYAELEYSMVESPVISNAMIDLGLKGEFYNIGQHKEPPFSPRPFLLPSQDTNMLYIGVSAFSINSAGFVYHRAGALCLYITNDMIPSGSLNRLNTRTFGKFIPQIGNMSPGLMMKLLVETVKEPIVTLEPNNMTVQASSKVTAYAIQPNSILSPLFVLKLEASVSAHIYVTGLKLAGHVTLNKIDMSLAESYVGPFQVTSLEDILTTVVKDVIIPKVNGKEGYPLPAIGKMQLVKSQLQVLKDYLLIGTDVTLTG
    

Molecular Weight49078.80 Da

Isoelectric Point (pI)9.33

Net Charge (pH 7.0)12.06

Net Charge (pH 7.4) 11.48

Charge Density (pH 7.0) 0.0267

GRAVY Index0.20

Hydrophobic Moment 0.76

Boman Index0.16

Instability Index31.12

Aliphatic Index 108.01

Aromaticity 0.0730

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40590.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225597 VERIFIED: NO

Provenance & Taxonomy

OrganismSinocyclocheilus grahami (Dianchi golden-line fish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria