Peptide Database

Peptide NameSLAY-screened peptide P5888

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC101H154N28O28S

DescriptionStandard

        MRVPSFPIPFGLHTNNLGNE
    

Molecular Weight2240.54 Da

Isoelectric Point (pI)6.52

Net Charge (pH 7.0)-0.40

Net Charge (pH 7.4) -0.68

Charge Density (pH 7.0) -0.0202

GRAVY Index-0.25

Hydrophobic Moment 0.30

Boman Index0.13

Instability Index27.28

Aliphatic Index 73.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 887.46

LogP -8.48

H-bond Donors 28.0

H-bond Acceptors 30.0

Rotatable Bonds 67.0

Heavy Atoms 158.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0100654 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/