Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length177 amino acids

Chemical FormulaC876H1380N238O235S7

DescriptionStandard

        PVALPAVHEPMLLLAVTEFVANSAAFVYFTAGALHRNISSDMLPRRFPLQLRTKSMGVFSPQLQEHYPDQPMELHLSARRQPLLSCRPDALHGALFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTISGNRLGGTVSLTGGLPILQVKRLETLLKFGLWLFGVPWANSECCPHAVP
    

Molecular Weight19230.24 Da

Isoelectric Point (pI)9.04

Net Charge (pH 7.0)3.47

Net Charge (pH 7.4) 3.04

Charge Density (pH 7.0) 0.0196

GRAVY Index0.22

Hydrophobic Moment 0.57

Boman Index0.17

Instability Index58.59

Aliphatic Index 101.41

Aromaticity 0.0791

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7372.56

LogP -75.97

H-bond Donors 253.0

H-bond Acceptors 251.0

Rotatable Bonds 605.0

Heavy Atoms 1356.0

Ring Count 39.0

Amide Bonds 189.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0062422 VERIFIED: NO

Provenance & Taxonomy

OrganismHerpetotheres cachinnans (Laughing falcon) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria