Peptide Database

Peptide NameSLAY-screened peptide P4928

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC73H125N27O23S

DescriptionStandard

        ARLHSKVREHSLSSAC
    

Molecular Weight1781.01 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)1.96

Net Charge (pH 7.4) 1.66

Charge Density (pH 7.0) 0.1226

GRAVY Index-0.51

Hydrophobic Moment 0.42

Boman Index-0.26

Instability Index38.86

Aliphatic Index 79.38

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 825.22

LogP -11.19

H-bond Donors 32.0

H-bond Acceptors 28.0

Rotatable Bonds 60.0

Heavy Atoms 124.0

Ring Count 2.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0144234 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/