Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length471 amino acids

Chemical FormulaC2302H3707N587O670S19

DescriptionStandard

        MFLCCWLGLVALIPTTLSTNPGVKVRLTEKGIEYGRQLGMAAIQQKLGSIKIPDFSGTEKVSPIGKVQYSLSNMHIVNVGLPKSSVDLVPGTGVTLSIGDAFISLNGNWRVKYLRIIKDSGSFDLDVNGLSIATTISIKSDETGRPAVSSDSCSATVGSAKVKFHGGASWLYNLFTTFINKALRNALQKQICPLVADAVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFYLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSITDDMIPKSSPIRLNTKTFGAFIPQIAKQFPGLMMKLLVKTVKTPTLTFEPNNATVQATTTVTAFAIQPNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLDKSNVGDFQVSALNSILQGVFQLVVIPTVNVQLAKGYPLPTIGKMKLMNTQLDVLKVRDTDNMLLLF
    

Molecular Weight50935.82 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)10.73

Net Charge (pH 7.4) 10.21

Charge Density (pH 7.0) 0.0228

GRAVY Index0.20

Hydrophobic Moment 0.72

Boman Index0.16

Instability Index32.43

Aliphatic Index 102.84

Aromaticity 0.0764

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353788 VERIFIED: NO

Provenance & Taxonomy

OrganismPundamilia nyererei [Bacterium]

FamilyBPI

Tax ID303518

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence