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MYP_164647
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Basic Information
salivaricin A2
Antimicrobial
Standard
22 amino acids
C105H158N28O32S3
Standard
Sequence
KRGTGWFATITDDCPNSVFVCC
Physicochemical Analysis
2420.74 Da
5.94
-0.27
-0.52
-0.0122
0.12
0.40
0.11
27.15
48.64
0.1364
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
967.95
-10.92
37.0
35.0
73.0
168.0
5.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0309326 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
three thionine rings: T9-C14, T11-C21, and S17-C22
Bio-Activity Profile
Antimicrobial
S.mutans JH1140
>128 μg/mL
MIC
PaperProduction of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.
RECORD: Rec_0322055 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
three thionine rings: T9-C14, T11-C21, and S17-C22
Bio-Activity Profile
Antimicrobial
Micrococcus luteus ATCC 10240
2 μg/mL
MIC
PaperProduction of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.
RECORD: Rec_0356496 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
three thionine rings: T9-C14, T11-C21, and S17-C22
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923
>128 μg/mL
MIC
PaperProduction of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.
RECORD: Rec_0362207 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
three thionine rings: T9-C14, T11-C21, and S17-C22
Bio-Activity Profile
Antimicrobial
C. accolens KPL 1818
16 μg/mL
MIC
PaperProduction of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.
RECORD: Rec_0363142 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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