Peptide Database

Peptide NameNeutrophil antibiotic peptide NP-2 (RatNP-2) (Neutrophil defensin 2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC437H718N132O139S8

DescriptionStandard

        MRTLTLLTALLLLALHTQAKSPQGTAEEAPDQEQLVMEDQDISISFGGDKGTALQDADVKAGVTCYCRSTRCGFRERLSGACGYRGRIYRLCCR
    

Molecular Weight10301.70 Da

Isoelectric Point (pI)7.58

Net Charge (pH 7.0)0.54

Net Charge (pH 7.4) 0.17

Charge Density (pH 7.0) 0.0058

GRAVY Index-0.24

Hydrophobic Moment 0.67

Boman Index-0.07

Instability Index31.27

Aliphatic Index 81.06

Aromaticity 0.0532

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4408.40

LogP -51.07

H-bond Donors 163.0

H-bond Acceptors 149.0

Rotatable Bonds 348.0

Heavy Atoms 716.0

Ring Count 8.0

Amide Bonds 99.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0312215 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)