Peptide Database

Peptide NameColicin-E2 (EC 3.1.-.-)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme / Catalytic activity ▸ Hydrolase ▸ Nuclease

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC393H638N120O115S

DescriptionStandard

        MEVGKDPELLKQFKNQNKVLVTKGKSSFVPESERVGERERFELHHIKRVTDGGAVYDIDNLRVVTPKHHIEIHRGNK
    

Molecular Weight8916.07 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)2.95

Net Charge (pH 7.4) 2.45

Charge Density (pH 7.0) 0.0384

GRAVY Index-0.87

Hydrophobic Moment 0.63

Boman Index-0.22

Instability Index44.94

Aliphatic Index 80.78

Aromaticity 0.0519

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3845.28

LogP -37.14

H-bond Donors 132.0

H-bond Acceptors 124.0

Rotatable Bonds 310.0

Heavy Atoms 629.0

Ring Count 12.0

Amide Bonds 82.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0104512 VERIFIED: NO

Provenance & Taxonomy

OrganismKlebsiella pneumoniae subsp. pneumoniae [Bacterium]

FamilyPyocin/Colicin

Tax ID72407

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Hydrolase Non-hemolytic Non-ribosomal

RECORD: Rec_0192589 VERIFIED: NO

Provenance & Taxonomy

OrganismEscherichia coli O6 [Bacterium]

FamilyPyocin/Colicin

Tax ID217992

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Endonuclease Hydrolase Nuclease Non-hemolytic Non-ribosomal

RECORD: Rec_0288533 VERIFIED: NO

Provenance & Taxonomy

OrganismEscherichia coli 908519 [Bacterium]

FamilyPyocin/Colicin

Tax ID1268991

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Endonuclease Hydrolase Nuclease Non-hemolytic Non-ribosomal

RECORD: Rec_0391999 VERIFIED: NO

Provenance & Taxonomy

OrganismEscherichia coli [Bacterium]

FamilyPyocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Bacteriocin Hydrolase Nuclease Endonuclease Non-hemolytic Non-ribosomal