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MYP_164297
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
10 amino acids
C57H87N21O11
Standard
Sequence
WWVAARAARR
Physicochemical Analysis
1242.43 Da
12.00
2.76
2.56
0.2760
-0.39
0.66
-0.24
57.79
69.00
0.2000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
542.50
-3.27
22.0
14.0
36.0
89.0
4.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0308637 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans 004 ATCC MYA-2876
20 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0314534 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Valerylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 700926
>20 μM
MIC
PaperZachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns. Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. Biopolymers. 2017 May;108(3). PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0319706 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Hemolytic
human red blood cells
1810 μM
HC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0341155 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 700926
805 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0381994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 6538
188 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
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