‹ ›
MYP_164297
← PREVIOUS NEXT → BACK
Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
10 amino acids
C57H87N21O11
Standard
Sequence
WWVAARAARR
Physicochemical Analysis
1242.43 Da
12.00
2.76
2.56
0.2760
-0.39
0.66
-0.24
57.79
69.00
0.2000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
542.50
-3.27
22.0
14.0
36.0
89.0
4.0
9.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0184431 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 700926
20 μM
MIC
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0186676 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Hemolytic
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0209449 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Valerylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis ATCC 29212
5.00 μM
MIC
PaperZachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns. Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. Biopolymers. 2017 May;108(3). PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0216070 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Valerylamide
Amidation
The Ⓧ (position: 4 and 8) in sequence indicates (S)-2-(4'-pentenyl)-alanine. Ⓧ (4) and Ⓧ (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antifungal
Candida albicans 004 ATCC MYA-2876
>20 μM
MIC
PaperZachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns. Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. Biopolymers. 2017 May;108(3). PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0217749 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli ATCC 700926
805 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
FIRST PREV 1 2 3 4 5 6 7 NEXT LAST
Showing 5 records on this page · Page 4 of 7