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MYP_164273
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
36 amino acids
C190H312N58O45S6
Standard
Sequence
LSKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS
Physicochemical Analysis
4321.26 Da
9.86
7.70
7.40
0.2139
0.22
0.63
-0.13
34.47
81.11
0.1389
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1712.82
-14.83
71.0
59.0
146.0
299.0
5.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063856 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 52.8%, T 19.4%, C 27.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Antimicrobial Cytotoxic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0097131 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://www.uniprot.org/uniprotkb/P28312/entry
RECORD: Rec_0255762 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli (see ref). Also killed Staphylococcus aureus based on virtual colony count assays (9.8 ug/ml killed 99.9%). This method exposed bacteria to peptides for 2 h in 10 mM phospahtate buffer before incubating in media for 12 h (Wang et al., 2023). Updated 7/2021, 2/2023
PaperStructure and diversity of the murine cryptdin gene family.
RECORD: Rec_0275772 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0325505 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
10090
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
7-35, 9-24, 14-34
Bio-Activity Profile
Antimicrobial
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