Peptide Database

Peptide NameSLAY-screened peptide P2074

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H162N28O32S2

DescriptionStandard

        TTMNRNTFTDYTCRSVPLFI
    

Molecular Weight2380.70 Da

Isoelectric Point (pI)7.89

Net Charge (pH 7.0)0.39

Net Charge (pH 7.4) 0.18

Charge Density (pH 7.0) 0.0194

GRAVY Index-0.21

Hydrophobic Moment 0.47

Boman Index-0.04

Instability Index44.95

Aliphatic Index 53.50

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 996.32

LogP -11.37

H-bond Donors 37.0

H-bond Acceptors 35.0

Rotatable Bonds 73.0

Heavy Atoms 166.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0377896 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/