Peptide Database

Peptide NameSLAY-screened peptide P955

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC90H137N31O22S2

DescriptionStandard

        PPHCRSRSGYCFRIRAY
    

Molecular Weight2069.38 Da

Isoelectric Point (pI)10.10

Net Charge (pH 7.0)4.02

Net Charge (pH 7.4) 3.88

Charge Density (pH 7.0) 0.2367

GRAVY Index-0.88

Hydrophobic Moment 0.22

Boman Index-0.35

Instability Index78.77

Aliphatic Index 28.82

Aromaticity 0.1765

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 863.34

LogP -9.21

H-bond Donors 36.0

H-bond Acceptors 29.0

Rotatable Bonds 62.0

Heavy Atoms 145.0

Ring Count 6.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0273902 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli (recombinant surface-display strain)

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/