Peptide Database

Peptide NameSLAY-screened peptide P5306

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC54H90N16O15

DescriptionStandard

        TAHVKTHPSIL
    

Molecular Weight1203.39 Da

Isoelectric Point (pI)8.47

Net Charge (pH 7.0)0.57

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0520

GRAVY Index0.02

Hydrophobic Moment 0.22

Boman Index0.15

Instability Index31.15

Aliphatic Index 106.36

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 489.60

LogP -4.66

H-bond Donors 17.0

H-bond Acceptors 18.0

Rotatable Bonds 36.0

Heavy Atoms 85.0

Ring Count 3.0

Amide Bonds 10.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0135217 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli (recombinant surface-display strain)

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/