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MYP_163974
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Basic Information
Nigroain-K2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
31 amino acids
C151H254N42O41S2
Standard
Sequence
SLWETIKNAGKGFILNILDKIRCKVAGGCKT
Physicochemical Analysis
3378.02 Da
9.59
3.44
3.19
0.1109
0.07
0.61
0.06
31.46
103.87
0.0645
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1365.58
-11.93
50.0
47.0
118.0
236.0
3.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0067741 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Pseudomonas aeruginosa PA01
25 μg/mL
MIC
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. PMID: 19778602. PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0075206 VERIFIED: YES
Provenance & Taxonomy
Hylarana maosonensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0102128 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Rabbit erythrocytes
100 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/19778602/ PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0107860 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.33 μM
MIC
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0111603 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
127021
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus ATCC25923
11.25 μg/mL
MIC
PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
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