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MYP_163970
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Basic Information
tuftsin
Anticancer
Antimicrobial
Delivery / Targeting ▸ Drug delivery vehicle ▸ Drug delivery
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Immunomodulation ▸ Immunoregulator
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Standard
4 amino acids
C21H40N8O6
Standard
Sequence
TKPR
Physicochemical Analysis
500.59 Da
11.00
1.40
1.21
0.3493
-2.67
0.34
-0.99
-30.20
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
249.98
-2.87
9.0
8.0
15.0
35.0
1.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301909 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Tuftsin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: 3-[(1-Nitroacridin-9-yl)amino]propanoic acid (nitroacrin) derivative
Bio-Activity Profile
Anticancer
A549, HL-60
PaperSolid phase synthesis and biological activity of tuftsin conjugates PMID21425770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21425770/
RECORD: Rec_0306999 VERIFIED: YES
Provenance & Taxonomy
Unknown [Animal]
tuftsin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive
Mammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperAntinociceptive action of the SP1-4 tetrapeptide and of some tuftsin analogs PMID1711198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1711198/
RECORD: Rec_0424522 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Tuftsin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: N-(4-Acetylphenyl)-5-bromo-2-hydroxybenzamide
Bio-Activity Profile
Antimicrobial Drug delivery
PaperEuropean Journal of Medicinal Chemistry. In vitro biological evaluation of new antimycobacterial salicylanilide-tuftsin conjugates. European Journal of Medicinal Chemistry. 2017 PMID28384546 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28384546/
RECORD: Rec_0424982 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Tuftsin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: acridone-4-carboxylic acid (4-carboxyacridone) derivative
Bio-Activity Profile
Anticancer
A549, HL-60
PaperSolid phase synthesis and biological activity of tuftsin conjugates PMID21425770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21425770/
RECORD: Rec_0427113 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory
PaperWieczorek Z., Zimecki M., S?o¨½ J. J., Siemion I. Z.. The immunomodulatory activity of tetra-and tripeptides of tuftsin-kentsin group. Peptides,15, 215-221, 1994. Evidence URLhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:88947
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