Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length99 amino acids

Chemical FormulaC481H760N138O148S4

DescriptionStandard

        KDSGRSTAYISKVFVTATFSTSLDSTGHASLSLNSCRTTSGDTDIKMNGKSGFLHDFFIKYLKKPIHRSLATNVSLSDCVGEHLRNITFTCQHWELGKR
    

Molecular Weight10972.28 Da

Isoelectric Point (pI)9.37

Net Charge (pH 7.0)5.17

Net Charge (pH 7.4) 4.65

Charge Density (pH 7.0) 0.0522

GRAVY Index-0.35

Hydrophobic Moment 0.77

Boman Index-0.04

Instability Index26.78

Aliphatic Index 70.91

Aromaticity 0.0909

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4643.24

LogP -56.59

H-bond Donors 171.0

H-bond Acceptors 162.0

Rotatable Bonds 368.0

Heavy Atoms 771.0

Ring Count 16.0

Amide Bonds 103.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0308996 VERIFIED: NO

Provenance & Taxonomy

OrganismColinus virginianus [Animal]

FamilyBPI

Tax ID9014

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence