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MYP_163870
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Basic Information
Beta-defensin CFDB-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
41 amino acids
C204H286N50O56S6
Standard
Sequence
FAVWGCADYRGYCRAACFAFEYSLGPKGCTEGYVCCVPNTF
Physicochemical Analysis
4527.14 Da
6.14
-0.30
-0.60
-0.0073
0.27
0.52
0.20
19.91
42.93
0.2195
11460.00
11835.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1671.95
-14.37
65.0
62.0
133.0
316.0
12.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160793 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
65 μg/mL
MIC
PMID24386139 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24386139/
RECORD: Rec_0244252 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 29.3%, T 34.1%, C 36.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0273761 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human RBC
400 μg/mL
Hemolysis
PMID24386139 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24386139/
RECORD: Rec_0286645 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923
65 μg/mL
MIC
PaperThe first salamander defensin antimicrobial peptide.
RECORD: Rec_0287292 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
rabbit RBC
400 μg/mL
Hemolysis
PMID24386139 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24386139/
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