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MYP_163870
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Basic Information
Beta-defensin CFDB-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
41 amino acids
C204H286N50O56S6
Standard
Sequence
FAVWGCADYRGYCRAACFAFEYSLGPKGCTEGYVCCVPNTF
Physicochemical Analysis
4527.14 Da
6.14
-0.30
-0.60
-0.0073
0.27
0.52
0.20
19.91
42.93
0.2195
11460.00
11835.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1671.95
-14.37
65.0
62.0
133.0
316.0
12.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013255 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 20032
100 μg/mL
MIC
PMID24386139 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24386139/
RECORD: Rec_0052505 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0066453 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic Anti-Gram-positive
Staphylococcus aureus
65 μg/mL
MIC
RECORD: Rec_0105902 VERIFIED: YES
Provenance & Taxonomy
Fuding fire [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID24781647 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24781647/
RECORD: Rec_0110643 VERIFIED: YES
Provenance & Taxonomy
Cynops fudingensis [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC25922
160 μg/mL
MIC
PMID24386139 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24386139/
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