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MYP_163836
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Basic Information
ApoE (131-162)+(244+272), hEP
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
61 amino acids
C327H539N101O93S
Standard
Sequence
EELRVRLASHLRKLRKRLLRDADDLQKRLAVYEEQAQQIRLQAEAFQARLKSWFEPLVEDM
Physicochemical Analysis
7405.46 Da
9.40
1.94
1.70
0.0318
-0.74
0.78
-0.30
60.51
102.46
0.0656
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3235.71
-26.05
114.0
97.0
261.0
522.0
7.0
66.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0106728 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Vesicular Stomatitis Virus (VSV) PsV
PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0132077 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0153309 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus (HCVpp) | Huh7.5.1 cells
0.67 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperHuman apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding. | Liu S, McCormick KD, Zhao W, Zhao T, Fan D, Wang T. | Hepatology. 2012 Aug;56(2):484-91. | DOI:10.1002/hep.25665 | PMID:22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0161332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0203224 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
cells
0.67 μM
IC50
PaperPubMed PMID: 22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
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