Peptide Database

Peptide NameNPP

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC376H578N114O123S6

DescriptionStandard

        QCWESNKCTDLSSEDGILECIKACKMDLSAESPVFPGNGHIQPLSENIRKYVMSHFRWNKFGRRNSTSNDNNNNNGGY
    

Molecular Weight8855.69 Da

Isoelectric Point (pI)6.90

Net Charge (pH 7.0)-0.09

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0012

GRAVY Index-0.94

Hydrophobic Moment 0.65

Boman Index-0.17

Instability Index94.76

Aliphatic Index 50.00

Aromaticity 0.0897

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3903.15

LogP -50.24

H-bond Donors 136.0

H-bond Acceptors 131.0

Rotatable Bonds 296.0

Heavy Atoms 619.0

Ring Count 14.0

Amide Bonds 90.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025576 VERIFIED: NO

Provenance & Taxonomy

OrganismLithobates catesbeiana [Animal]

FamilyPOMC

Tax ID8400

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Other ModsPhe61 Amidation

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor

RECORD: Rec_0026026 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0141528 VERIFIED: YES

Provenance & Taxonomy

OrganismAquarana catesbeiana [Animal]

FamilyNPP

Tax ID8400

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods61:Phenylalanine amide; 65:N-linked (GlcNAc...) asparagine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour