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MYP_163792
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Basic Information
DC2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C138H219N37O45S6
Standard
Sequence
GAVPCGETCVYLPCITPDIGCSCQNKVCYRD
Physicochemical Analysis
3308.83 Da
4.78
-1.29
-1.59
-0.0417
0.18
0.32
0.11
12.30
69.03
0.0645
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1297.10
-14.94
49.0
50.0
100.0
226.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0176005 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Anticancer Cytotoxic
RECORD: Rec_0202876 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0252819 VERIFIED: YES
Provenance & Taxonomy
Melicytus dentatus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0369316 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PC-3
2.65 μM
IC50
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0378470 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
LNCaP
4.31 μM
IC50
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
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