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MYP_163792
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Basic Information
DC2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C138H219N37O45S6
Standard
Sequence
GAVPCGETCVYLPCITPDIGCSCQNKVCYRD
Physicochemical Analysis
3308.83 Da
4.78
-1.29
-1.59
-0.0417
0.18
0.32
0.11
12.30
69.03
0.0645
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1297.10
-14.94
49.0
50.0
100.0
226.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0040230 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0043064 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0082565 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Cycloviolin C. Mol. Wt: 3414.0; GRAVY=0.506. Kill human prostate cancer cells: LNcap
4.3 μM
IC50
PaperNovel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells
RECORD: Rec_0105846 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
DU145
3.11 μM
IC50
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0113660 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
prostate cancer cells
2.65 μM
IC50
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