Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2360H3715N607O690S21

DescriptionStandard

        MLPAVIALLMLLSCTSGQNPAIQVILTNKGLQYGKHTGVGLIQEKLESITLPDISGEVDIKIGRVHYTLTGIAVKQCDLPEPSVQFFQDAAGFKTSSLGLNAALAGGWRTRFGIIHDGGSFDMTMFGVDVTSVVGLGKDPDGHLFITSISCDAVVGDVNINFHGGASFMFQPFVRYFKGRIRNEIQSGICSAVNGSVEKLELHLQAMNVSFDVNEVLTLDLPLTGTPIIDASRLNLGLKGEFYSIRAHKEPPFKAQPFTMPQQPDFMLSVGLSDFTLNSASYGYYSDGLLQILIDDSMIPPTSPIHLNTTYMGMFAPQLPEKFPGLLMDLQVYAREAPMFSFQSGAAKLISLVDVKAFAIEPNGTQVPLFKLNVDSKFSTKLWISGGSLKGSMTMDNFTVTLAASEVGQVKTDALERSLTVAIKATVLPKVNDALSKGWILPRMKHAQLVNSVLKMEEVSDNKIAHYDVTGTFNWEHKGSLG
    

Molecular Weight52304.76 Da

Isoelectric Point (pI)5.89

Net Charge (pH 7.0)-6.54

Net Charge (pH 7.4) -7.47

Charge Density (pH 7.0) -0.0136

GRAVY Index0.11

Hydrophobic Moment 0.66

Boman Index0.16

Instability Index33.98

Aliphatic Index 95.46

Aromaticity 0.0851

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0009053 VERIFIED: NO

Provenance & Taxonomy

OrganismAcanthochromis polyacanthus [Bacterium]

FamilyBPI

Tax ID80966

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence