Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2572H4007N647O737S18

DescriptionStandard

        MRTKAVQVLWGYFFLWSLHISSAQTIYPGIKARVTQRALDYGVLAGMDMIEQMVKERKIPDLRGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIRSPLFQDTGGADLFLSGVYFTGIIVLARNGFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYMELNLKGVFYPLDNLTDPPFSPVPFVLPERSDSMLYVGISEFFFKSASFAYFTAGAFNVTLSMKEISNHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPGNFTLDIPASIVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENVLSSILHFGILPLANAKLQQGIPLPNPRKISFVNSDIEVFEGFLLISTDLKYEMSLKQQPSFHGWEGLNLISGQWRGKPAA
    

Molecular Weight56361.39 Da

Isoelectric Point (pI)5.40

Net Charge (pH 7.0)-9.77

Net Charge (pH 7.4) -10.54

Charge Density (pH 7.0) -0.0193

GRAVY Index0.18

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index38.63

Aliphatic Index 103.63

Aromaticity 0.1045

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51465.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0263311 VERIFIED: NO

Provenance & Taxonomy

OrganismUrsus americanus [Animal]

FamilyBPI

Tax ID9643

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence