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MYP_163705
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Basic Information
Pa-AMP1 (PAFP-S)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
38 amino acids
C163H253N51O51S6
Standard
Sequence
AGCIKNGGRCNASAGPPYCCSSYCFQIAGQSYGVCKNR
Physicochemical Analysis
3935.45 Da
8.90
3.73
3.45
0.0982
-0.23
0.48
0.01
26.26
38.68
0.1053
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1655.34
-24.46
63.0
61.0
124.0
271.0
6.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014796 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Knottin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-10; 23-27; 32-36; 14-19; 4-8; 11-14; 19-22; 28-32
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Bacillus megaterium
8 μg/mL
IC50
PaperPubMed PMID 10759497 | PubMed PMID 10082950 | Gao et al., 2001 PMID10759497;10082950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10759497/
RECORD: Rec_0037387 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0040211 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Bacillus megaterium
8 μg/mL
IC50
PaperA new antifungal peptide from the seeds of Phytolacca americana: characterization, amino acid sequence and cDNA cloning
RECORD: Rec_0040639 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Gurmarin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Gram +ve bacteria
PMID10759497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10759497/
RECORD: Rec_0061077 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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