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MYP_163693
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Basic Information
Brevinin-1CSa
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C123H208N28O26S2
Standard
Sequence
FLPILAGLAAKIVPKLFCLATKKC
Physicochemical Analysis
2559.27 Da
9.70
3.74
3.50
0.1557
1.25
0.50
0.39
31.07
142.50
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-1.51
30.0
32.0
83.0
179.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0157474 VERIFIED: NO
Provenance & Taxonomy
Rana cascadae [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Hemolytic Non-ribosomal
Escherichia coli, Staphylococcus aureus
Qualitative functional evidence
PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/; https://www.uniprot.org/uniprotkb/P0DTL9/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0185385 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0209503 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
2.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 28 (2007) 1268-1274. Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
RECORD: Rec_0263921 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli and, Staphylococcus aureus
32 μM
MIC
RECORD: Rec_0272279 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
2 μM
MIC
PaperPeptide defenses of the cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group
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