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MYP_163685
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Basic Information
Islet amyloid polypeptide
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Standard
37 amino acids
C167H273N51O55S2
Standard
Sequence
KCNTATCATQRLTNFLVRSSHNLGAALLPTDVGSNTY
Physicochemical Analysis
3939.39 Da
8.90
1.83
1.54
0.0494
-0.14
0.64
0.01
19.08
79.19
0.0541
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1735.68
-24.58
63.0
60.0
126.0
275.0
4.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0171121 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Islet amyloid polypeptide
10141
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Mammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Islet amyloid polypeptide (Cavia porcellus): PMID 2668946 PMID2668946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2668946/
RECORD: Rec_0196823 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0344325 VERIFIED: NO
Provenance & Taxonomy
Cavia porcellus [Animal]
Calcitonin
10141
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Hormone Calcium-regulatory peptide
Evidence URLhttps://www.uniprot.org/uniprotkb/IAPP_CAVPO/entry
RECORD: Rec_0397160 VERIFIED: NO
Provenance & Taxonomy
Cavia porcellus [Animal]
10141
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone