Peptide Database

Peptide NameKR-12-a3

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC76H138N26O13

DescriptionStandard

        KRIVKRIKKWLR
    

Molecular Weight1624.08 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.55

Charge Density (pH 7.0) 0.5630

GRAVY Index-1.08

Hydrophobic Moment 1.06

Boman Index-0.66

Instability Index73.28

Aliphatic Index 121.67

Aromaticity 0.0833

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 688.99

LogP -2.44

H-bond Donors 27.0

H-bond Acceptors 20.0

Rotatable Bonds 60.0

Heavy Atoms 115.0

Ring Count 2.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0421334 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic

Targethuman red blood cells

Activity800 μM

MethodHC50

PaperShort KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity. J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. PMID: 24105706. PMID24105706 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24105706/

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