Peptide Database

Peptide Namevpr signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC170H277N41O42S

DescriptionStandard

        MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSK
    

Molecular Weight3599.33 Da

Isoelectric Point (pI)11.26

Net Charge (pH 7.0)3.50

Net Charge (pH 7.4) 3.28

Charge Density (pH 7.0) 0.1029

GRAVY Index1.01

Hydrophobic Moment 0.48

Boman Index0.36

Instability Index14.21

Aliphatic Index 117.65

Aromaticity 0.1176

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1319.26

LogP -9.46

H-bond Donors 47.0

H-bond Acceptors 47.0

Rotatable Bonds 119.0

Heavy Atoms 254.0

Ring Count 5.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0402187 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization L-Asparaginase secretion

TargetBacillus subtilis WB600

Activity1.0 U/mL

MethodAsparaginase activity assay

PaperFeng Y, Liu S, Jiao Y, et al. Enhanced extracellular production of L-asparaginase from Bacillus subtilis 168 by B-subtilis WB600 through a combined strategy[J]. Applied Microbiology and Biotechnology, 2017, 101(4): 1509-1520 PMID27796436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27796436/