Peptide Database

Peptide NameToxin CsEv3

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC307H465N79O98S8

DescriptionStandard

        KEGYLVNKSTGCKYGCLKLGENEGCDKECKAKNQGGSYGYCYAFACWCEGLPESTPTYPLPNKSC
    

Molecular Weight7086.97 Da

Isoelectric Point (pI)7.66

Net Charge (pH 7.0)0.68

Net Charge (pH 7.4) 0.33

Charge Density (pH 7.0) 0.0105

GRAVY Index-0.70

Hydrophobic Moment 0.35

Boman Index-0.05

Instability Index51.47

Aliphatic Index 39.08

Aromaticity 0.1231

Extinction Coeff. Reduced 14440.00

Extinction Coeff. Oxidized 14940.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2854.05

LogP -32.25

H-bond Donors 104.0

H-bond Acceptors 107.0

Rotatable Bonds 230.0

Heavy Atoms 492.0

Ring Count 13.0

Amide Bonds 69.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0176623 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides sculpturatus [Animal]

FamilySodium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide12-65; 16-41; 25-46; 29-48

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense